Ongoing Challenges to Understanding and Interrupting Environmental Enteric Dysfunction
نویسندگان
چکیده
منابع مشابه
Environmental enteric dysfunction: an overview.
BACKGROUND Environmental enteric dysfunction (EED) refers to an incompletely defined syndrome of inflammation, reduced absorptive capacity, and reduced barrier function in the small intestine. It is widespread among children and adults in low- and middle-income countries. Understanding of EED and its possible consequences for health is currently limited. OBJECTIVE A narrative review of the cu...
متن کاملSecondary Carnitine Deficiency in Environmental Enteric Dysfunction
Article history: Received 14 February 2017 Accepted 14 February 2017 Available online 16 February 2017 score so as to have a composite index for EED (Kosek et al., 2013). In this study, the plasma from the children was analyzed by LC-MS using a discovery platform and 677 metabolites were definitively identified with relative quantitation. Using a false discovery rate approach, 77 of these metab...
متن کاملAn Exposome Perspective on Environmental Enteric Dysfunction
BACKGROUND Environmental exposures to chemicals have been shown to influence gastrointestinal function, yet little is known regarding whether chemical mixtures may be involved in the development of a subclinical enteric dysfunction found in infants and children born into poor hygiene and sanitation. Advances in gastrointestinal and immunotoxicology fields merit inclusion in complex discussions ...
متن کاملEnvironmental Enteric Dysfunction: Advancing Current Knowledge
when available) was reviewed by two analysts to determine inclusion status for the EED Library. Dual review reduces bias and inaccuracies in the systematic review process. The principal investigators (DMD and PIT) initially piloted the Library inclusion process, until 100% concordance was achieved upon independent review of 1,300 consecutive references. A series of training sessions to convey t...
متن کاملAssessment of Environmental Enteric Dysfunction in the SHINE Trial: Methods and Challenges
Environmental enteric dysfunction (EED) is a virtually ubiquitous, but poorly defined, disorder of the small intestine among people living in conditions of poverty, which begins early in infancy and persists. EED is characterized by altered gut structure and function, leading to reduced absorptive surface area and impaired intestinal barrier function. It is hypothesized that recurrent exposure ...
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ژورنال
عنوان ژورنال: The Journal of Pediatrics
سال: 2019
ISSN: 0022-3476
DOI: 10.1016/j.jpeds.2019.02.043